Protein name:
Platelet endothelial cell adhesion molecule (PECAM-1) ;
Alternative:
CD:
CD31 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ (By similarity). Interacts with FER. Interacts with PTPN11; Tyr-714 is critical for PTPN11 recruitment.
Function:
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-689 plays a critical role in transendothelial migration (TEM) and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of CD31 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of CD31 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation. Induces susceptibility to atherosclerosis.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Cell junction
Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Protein Attributes:
50:
MQLRWTQRGM | MWLGALLTLL | LCSSLKGQEN | SFTINSIHMQ | ILPHSTVQNG |
100:
ENLTLQCLVD | VSTTSRVKPL | HQVLFYKDDV | LLHNVSSRRN | TESYLIPHVR |
150:
VCDSGRYKCN | VILNNKEKTT | PEYEVWVKGV | SDPRVTLDKK | EVIEGGVVVV |
200:
NCSVPEEKAP | VHFTIEKFEL | NIRGAKKKRE | KTSQNQNFVT | LEFTVEEQDR |
250:
TIRFQCQAKI | FSGSNVESSR | PIQSDLVTVR | ESFSNPKFHI | IPEGKVMEGD |
300:
DLQVKCTVQV | THQAQSFPEI | IIQKDREIVA | HNSLSSEAVY | SVMATTEHNG |
350:
NYTCKVEASR | ISKVSSVVVN | VTELFSKPKL | ESSATHLDQG | EDLNLLCSIP |
400:
GAPPANFTIQ | KGGMTVSQTQ | NFTKRVSEWD | SGLYTCVAGV | GRVFKRSNTV |
450:
QITVCEMLSK | PSIFHDSRSE | VIKGQTIEVS | CQSVNGTAPI | FYQLSNTSKP |
500:
VANQSVGSNK | PAIFRVKPTK | DVEYCCSADN | CHSHSKMFSE | VLRVKVIAPV |
550:
DEAQLVVLKG | EVEPGEPIVF | YCSVNEGSFP | ITYKFYKEKE | SKPFYQDTIN |
600:
ATQIMWHKTT | ASKEYEGQYY | CTASNRANLS | KHVIQSNTLT | VRVYLPLEKG |
650:
LIAVVVIGVI | IVTLVLGAKC | YFLKKAKAKQ | MPVEMSRPAV | PLLNSNNEKT |
700:
LSDAGTEADR | HYGYNEDVGN | HAMKPLNENK | EPLTLDVEYT | EVEVTSPEPH |
739:
QGLGTKGTET | ETVYSEIRKA | DPDFVENRYS | RTEGSLDGS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Pig
Bovine
Mouse
ELISA Kit for Bovine PECAM-1
ELISA Kit for Bovine PECAM-1
ELISA Kit for Bovine PECAM-1
ELISA Kit for Bovine PECAM-1
ELISA Kit for Bovine PECAM-1
CLIA Kit for Bovine PECAM-1
CLIA Kit for Bovine PECAM-1
CLIA Kit for Bovine PECAM-1
CLIA Kit for Bovine PECAM-1
CLIA Kit for Bovine PECAM-1
Polyclonal Antibody for Bovine PECAM-1
Polyclonal Antibody for Bovine PECAM-1
Polyclonal Antibody for Bovine PECAM-1
Polyclonal Antibody for Bovine PECAM-1
Polyclonal Antibody for Bovine PECAM-1
Monoclonal Antibody for Bovine PECAM-1
Monoclonal Antibody for Bovine PECAM-1
Monoclonal Antibody for Bovine PECAM-1
Monoclonal Antibody for Bovine PECAM-1
Monoclonal Antibody for Bovine PECAM-1
Protein for Bovine PECAM-1
Protein for Bovine PECAM-1
Protein for Bovine PECAM-1
Protein for Bovine PECAM-1
Protein for Bovine PECAM-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-689 AND TYR-714;MUTAGENESIS OF TYR-689 AND TYR-714;INTERACTION WITH FER AND PTPN11